| Accession | TIGR00347 |
| Name | bioD |
| Function | dethiobiotin synthase |
| Gene Symbol | bioD |
| Trusted Cutoff | 83.30 |
| Domain Trusted Cutoff | 83.30 |
| Noise Cutoff | 56.05 |
| Domain Noise Cutoff | 56.05 |
| Isology Type | equivalog |
| EC Number | 6.3.3.3 |
| HMM Length | 166 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Biotin |
| Gene Ontology Term | GO:0004141: dethiobiotin synthase activity molecular_function |
| | GO:0009102: biotin biosynthetic process biological_process |
| Author | Loftus BJ |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Dethiobiotin synthase is involved in biotin biosynthesis and catalyses the reaction (CO2 + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP). The enzyme binds ATP (see motif in first 12 residues of the SEED alignment) and requires magnesium as a co-factor. |
| References | DR SWISSPROT; P13000;
DR ECOCYC; EG10120; bioD;
RM 97270412
RT Active site mutants of Escherichia coli dethiobiotin synthetase: effects of mutations on enzyme catalytic and structural properties.
RA Yang G, Sandalova T, Lohman K, Lindqvist Y, Rendina AR
RL Biochemistry 1997 Apr 22;36(16):4751-60
SE TIGR
GA hmmls
DR HAMAP; MF_00336; 181 of 183 |
| Genome Property | GenProp0036: biotin biosynthesis (HMM) |
