HMM Summary Page: TIGR00364

Functionqueuosine biosynthesis protein QueC
Gene SymbolqueC
Trusted Cutoff150.30
Domain Trusted Cutoff150.30
Noise Cutoff86.20
Domain Noise Cutoff86.20
Isology Typeequivalog
HMM Length201
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are QueC, involved in synthesizing pre-Q0 from GTP en route to tRNA modification with queuosine. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In Rhizobium meliloti, the gene was designated exsB, possibly because of polar effects on exsA expression in a shared polycistronic mRNA. In Arthrobacter viscosus, the homologous gene was designated ALU1 and was associated with an aluminum tolerance phenotype.
ReferencesRN [1] RM PMID:16199558 RT Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli. RA Gaur R, Varshney U RL J Bacteriol. 2005 Oct;187(20):6893-901. RN [2] RM PMID: 14660578 RT Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine. RA Reader JS, Metzgar D, Schimmel P, de Crecy-Lagard V RL J Biol Chem. 2004 Feb 20;279(8):6280-5. RN [3] RM 9045825 RT Functional analysis of exsC and exsB in regulation of exoenzyme S production by Pseudomonas aeruginosa. RA Goranson J, Hovey AK, Frank DW. RL J Bacteriol 1997 Mar;179(5):1646-54 RN [4] RM 98042479 RT Isolation of ALU1-P gene encoding a protein with aluminum tolerance activity from Arthrobacter viscosus. RA Jo J, Jang YS, Kim KY, Kim MH, Kim IJ, Chung WI RL Biochem Biophys Res Commun 1997 Oct 29;239(3):835-9 SE TIGR GA hmmls AL clustalw, belvu DR HAMAP; MF_01633; 386 of 392