| Accession | TIGR00379 |
| Name | cobB |
| Function | cobyrinic acid a,c-diamide synthase |
| Gene Symbol | cobB |
| Trusted Cutoff | 261.40 |
| Domain Trusted Cutoff | 261.40 |
| Noise Cutoff | 152.40 |
| Domain Noise Cutoff | 152.40 |
| Isology Type | equivalog |
| EC Number | 6.3.1.- |
| HMM Length | 449 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Heme, porphyrin, and cobalamin |
| Gene Ontology Term | GO:0005737: cytoplasm cellular_component |
| | GO:0009236: cobalamin biosynthetic process biological_process |
| | GO:0042242: cobyrinic acid a,c-diamide synthase activity molecular_function |
| Author | Loftus BJ |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes cobyrinic acid a,c-diamide synthase, the cobB (cbiA in Salmonella) protein of cobalamin biosynthesis. It is responsible for the amidation of carboxylic groups at positions A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine and one molecule of ATP hydrogenolyzed for each amidation. |
| References | DR SWISSPROT; P21632;
SE TIGR
GA hmmls
DR HAMAP; MF_00027; 53 of 53 |
| Genome Property | GenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM) |
| | GenProp0275: cobyrinic acid diamide biosynthesis, anaerobic pathway (HMM) |
