HMM Summary Page: TIGR00384

Functionsuccinate dehydrogenase and fumarate reductase iron-sulfur protein
Trusted Cutoff88.00
Domain Trusted Cutoff88.00
Noise Cutoff78.25
Domain Noise Cutoff78.25
Isology Typesubfamily
HMM Length222
Mainrole CategoryEnergy metabolism
Subrole CategoryAerobic
Gene Ontology TermGO:0000104: succinate dehydrogenase activity molecular_function
GO:0006099: tricarboxylic acid cycle biological_process
GO:0009060: aerobic respiration biological_process
GO:0009061: anaerobic respiration biological_process
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentSuccinate dehydrogenase and fumarate reductase are reverse directions of the same enzymatic interconversion, succinate + FAD+ = fumarate + FADH2 (EC In E. coli, the forward and reverse reactions are catalyzed by distinct complexes: fumarate reductase operates under anaerobic conditions and succinate dehydrogenase operates under aerobic conditions. This model also describes a region of the B subunit of a cytosolic archaeal fumarate reductase.
ReferencesA2 hmmalign RM 98237600; RT Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum--identification of the catalytic sites for fumarate reduction and thiol oxidation. RA Heim S, Kunkel A, Thauer RK, Hedderich R RL Eur J Biochem 1998 Apr 1;253(1):292-9 DR SWISSPROT; P07014; DR SWISSPROT; P44893; DR EGAD; 20011; DR PROSITE; PS00198; 4FE4S_FERREDOXIN; DR PFAM; PF00037; fer4; SE TIGR GA hmmls AL clustalw, belvu BD 0501
Genome PropertyGenProp0033: TCA cycle (HMM)
GenProp0756: fumarate reductase complex (HMM)