HMM Summary Page: TIGR00396

Functionleucine--tRNA ligase
Gene SymbolleuS
Trusted Cutoff548.40
Domain Trusted Cutoff548.40
Noise Cutoff335.30
Domain Noise Cutoff335.30
Isology Typeequivalog
EC Number6.1.1.4
HMM Length843
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004823: leucine-tRNA ligase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0006429: leucyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches.
ReferencesSE TIGR GA hmmls AL clustalw, seaview, belvu DR HAMAP; MF_00049; 507 of 550
Genome PropertyGenProp0258: tRNA aminoacylation (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)