HMM Summary Page: TIGR00399

Functionmethionine--tRNA ligase, beta subunit
Gene SymbolmetG
Trusted Cutoff116.65
Domain Trusted Cutoff116.65
Noise Cutoff64.45
Domain Noise Cutoff64.45
Isology Typeequivalog_domain
EC Number6.1.1.10
HMM Length139
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004825: methionine-tRNA ligase activity molecular_function
GO:0006431: methionyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This HMM describes a region of the methionyl-tRNA synthetase that is present at the C-terminus of MetG in some species (E. coli, B. subtilis, Thermotoga maritima, Methanobacterium thermoautotrophicum), and as a separate beta chain in Aquifex aeolicus. It is absent in a number of other species (e.g. Mycoplasma genitalium, Mycobacterium tuberculosis), while Pyrococcus horikoshii has both a full length MetG and a second protein homologous to the beta chain only. Proteins hit by this HMM should called methionyl-tRNA synthetase beta chain if and only if the HMM metG hits a separate protein not also hit by this HMM.
ReferencesDR EC SE TIGR GA hmmls DR HAMAP; MF_01228; 16 of 38
Genome PropertyGenProp0258: tRNA aminoacylation (HMM)