HMM Summary Page: TIGR00435

Functioncysteine--tRNA ligase
Gene SymbolcysS
Trusted Cutoff340.00
Domain Trusted Cutoff340.00
Noise Cutoff266.85
Domain Noise Cutoff266.85
Isology Typeequivalog
EC Number6.1.1.16
HMM Length466
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004817: cysteine-tRNA ligase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0006423: cysteinyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln).
ReferencesRL Nucleic Acids Symp Ser 1997;(37):305-6. Aminoacyl-tRNA synthesis in Archaea. RA Ibba M, Celic I, Curnow A, Kim H, Pelaschier J, Tumbula D, Vothknecht U, Woese C, Soll D. RM Medline; 98247213 SE TIGR GA hmmls AL clustalw, seaview, belvu DR HAMAP; MF_00041; 522 of 530
Genome PropertyGenProp0258: tRNA aminoacylation (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)