HMM Summary Page: TIGR00441

Functionphosphoheptose isomerase
Gene SymbolgmhA
Trusted Cutoff209.45
Domain Trusted Cutoff209.45
Noise Cutoff176.20
Domain Noise Cutoff176.20
Isology Typeequivalog
EC Number5.3.1.28
HMM Length154
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0008968: D-sedoheptulose 7-phosphate isomerase activity molecular_function
GO:0009244: lipopolysaccharide core region biosynthetic process biological_process
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes phosphoheptose isomerase. Because a closely related paralo in Escherichia coli differs in function (DnaA initiator-associating protein diaA), this model has been rebuilt with a high stringency, and is likely to miss many true examples for phosphoheptose isomerase. Involved in lipopolysaccharide biosynthesis it may have a role in virulence in Haemophilus ducreyi.
ReferencesRN [1] RM PMID:18056714 RT Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants. RA Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS RL J Biol Chem. 2008 Feb 1;283(5):2835-45. Epub 2007 Dec 3. DR Swissprot; P51001 DR ECOCYC; EG13146; SE TIGR DR HAMAP; MF_01157; 32 of 33
Genome PropertyGenProp0203: LPS inner core biosynthesis, ketodeoxyoctonate and heptose type (HMM)