HMM Summary Page: TIGR00463

Functionglutamate--tRNA ligase
Gene SymbolgltX
Trusted Cutoff401.75
Domain Trusted Cutoff401.75
Noise Cutoff384.75
Domain Noise Cutoff384.75
Isology Typeequivalog
EC Number6.1.1.17
HMM Length560
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004818: glutamate-tRNA ligase activity molecular_function
GO:0006424: glutamyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedOct 11 2011 12:16PM
CommentThe glutamyl-tRNA synthetases of the eukaryotic cytosol and of the Archaea are more similar to glutaminyl-tRNA synthetases than to bacterial glutamyl-tRNA synthetases. This HMM models just the eukaryotic cytosolic and archaeal forms of the enzyme. In some eukaryotes, the glutamyl-tRNA synthetase is part of a longer, multifunctional aminoacyl-tRNA ligase. In many species, the charging of tRNA(gln) proceeds first through misacylation with Glu and then transamidation. For this reason, glutamyl-tRNA synthetases, including all known archaeal enzymes (as of 2010) may act on both tRNA(gln) and tRNA(glu).
ReferencesSE TIGR GA hmmls DR HAMAP; MF_00022; 42 of 565
Genome PropertyGenProp0217: 5-aminolevulinate biosynthesis (glutamate pathway) (HMM)
GenProp0258: tRNA aminoacylation (HMM)
GenProp0831: archaeal core gene set, exactly 1 per genome (HMM)