HMM Summary Page: TIGR00468

Functionphenylalanine--tRNA ligase, alpha subunit
Gene SymbolpheS
Trusted Cutoff237.45
Domain Trusted Cutoff237.45
Noise Cutoff190.65
Domain Noise Cutoff190.65
Isology Typeequivalog
EC Number6.1.1.20
HMM Length324
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004826: phenylalanine-tRNA ligase activity molecular_function
GO:0006432: phenylalanyl-tRNA aminoacylation biological_process
GO:0009328: phenylalanine-tRNA ligase complex cellular_component
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentMost phenylalanyl-tRNA synthetases are heterodimeric, with 2 alpha (pheS) and 2 beta (pheT) subunits. This HMM describes the alpha subunit, which shows some similarity to class II aminoacyl-tRNA ligases. Mitochondrial phenylalanyl-tRNA synthetase is a single polypeptide chain, active as a monomer, and similar to this chain rather than to the beta chain, but excluded from this model. An interesting feature of the alignment of all sequences captured by this model is a deep split between non-spirochete bacterial examples and all other examples; supporting this split is a relative deletion of about 50 residues in the former set between two motifs well conserved throughout the alignment.
ReferencesSE TIGR GA hmmls AL clustalw_manual DR HAMAP; MF_00282; 32 of 32
Genome PropertyGenProp0258: tRNA aminoacylation (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)
GenProp0831: archaeal core gene set, exactly 1 per genome (HMM)