| Accession | TIGR00482 |
| Name | TIGR00482 |
| Function | nicotinate (nicotinamide) nucleotide adenylyltransferase |
| Gene Symbol | nadD |
| Trusted Cutoff | 112.45 |
| Domain Trusted Cutoff | 112.45 |
| Noise Cutoff | 63.85 |
| Domain Noise Cutoff | 63.85 |
| Isology Type | equivalog |
| EC Number | 2.7.7.18 |
| HMM Length | 194 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pyridine nucleotides |
| Gene Ontology Term | GO:0000309: nicotinamide-nucleotide adenylyltransferase activity molecular_function |
| | GO:0004515: nicotinate-nucleotide adenylyltransferase activity molecular_function |
| | GO:0005737: cytoplasm cellular_component |
| | GO:0009435: NAD biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the predominant bacterial/eukaryotic adenylyltransferase for nicotinamide-nucleotide, its deamido form nicotinate nucleotide, or both. The first activity, nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1), synthesizes NAD by the salvage pathway, while the second, nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) synthesizes the immediate precursor of NAD by the de novo pathway. In E. coli, NadD activity is biased toward the de novo pathway while salvage activity is channeled through the multifunctional NadR protein, but this division of labor may be exceptional. The given name of this model, nicotinate (nicotinamide) nucleotide adenylyltransferase, reflects the lack of absolute specificity with respect to substrate amidation state in most species. |
| References | SE TIGR
AL clustalw_manual
DR HAMAP; MF_00244; 278 of 287 |
| Genome Property | GenProp0057: NAD(P) biosynthesis from L-aspartate and DHAP (HMM) |
