HMM Summary Page: TIGR00484

Functiontranslation elongation factor G
Gene SymbolfusA
Trusted Cutoff659.40
Domain Trusted Cutoff659.40
Noise Cutoff215.15
Domain Noise Cutoff215.15
Isology Typeequivalog
HMM Length691
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0003746: translation elongation factor activity molecular_function
GO:0006414: translational elongation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentAfter peptide bond formation, this elongation factor of bacteria and organelles catalyzes the translocation of the tRNA-mRNA complex, with its attached nascent polypeptide chain, from the A-site to the P-site of the ribosome. Every completed bacterial genome has at least one copy, but some species have additional EF-G-like proteins. The closest homolog to canonical (e.g. E. coli) EF-G in the spirochetes clusters as if it is derived from mitochondrial forms, while a more distant second copy is also present. Synechocystis PCC6803 has a few proteins more closely related to EF-G than to any other characterized protein. Two of these resemble E. coli EF-G more closely than does the best match from the spirochetes; it may be that both function as authentic EF-G.
ReferencesSE TIGR GA hmmls AL clustalw DR HAMAP; MF_00054; 559 of 618
Genome PropertyGenProp0741: translation elongation, bacterial (HMM)
GenProp0800: bacterial core gene set, 1 or more per genome (HMM)