| Accession | TIGR00491 |
| Name | aIF-2 |
| Function | translation initiation factor aIF-2 |
| Gene Symbol | infB |
| Trusted Cutoff | 554.75 |
| Domain Trusted Cutoff | 554.75 |
| Noise Cutoff | 393.05 |
| Domain Noise Cutoff | 393.05 |
| Isology Type | equivalog |
| HMM Length | 594 |
| Mainrole Category | Protein synthesis |
| Subrole Category | Translation factors |
| Gene Ontology Term | GO:0003743: translation initiation factor activity molecular_function |
| | GO:0006413: translational initiation biological_process |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes archaeal and eukaryotic orthologs of bacterial IF-2. Like IF-2, it helps convey the initiator tRNA to the ribosome, although the initiator is N-formyl-Met in bacteria and Met here. This protein is not closely related to the subunits of eIF-2 of eukaryotes, which is also involved in the initiation of translation. The aIF-2 of Methanococcus jannaschii contains a large intein interrupting a region of very strongly conserved sequence very near the amino end; the alignment generated by this HMM does not correctly align the sequences from Methanococcus jannaschii and Pyrococcus horikoshii in this region. |
| References | DR MUID 98288357
SE TIGR
GA hmmls
DR HAMAP; MF_00100; 43 of 608 |
| Genome Property | GenProp0815: archaeal-only core gene set (HMM) |
| | GenProp0831: archaeal core gene set, exactly 1 per genome (HMM) |
