| Accession | TIGR00492 |
| Name | alr |
| Function | alanine racemase |
| Gene Symbol | alr |
| Trusted Cutoff | 168.00 |
| Domain Trusted Cutoff | 168.00 |
| Noise Cutoff | 129.90 |
| Domain Noise Cutoff | 129.90 |
| Isology Type | equivalog |
| EC Number | 5.1.1.1 |
| HMM Length | 369 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of murein sacculus and peptidoglycan |
| Gene Ontology Term | GO:0008784: alanine racemase activity molecular_function |
| | GO:0009252: peptidoglycan biosynthetic process biological_process |
| Author | Anolik RT, Richardson DL |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme interconverts L-alanine and D-alanine. Its primary function is to generate D-alanine for cell wall formation. With D-alanine-D-alanine ligase, it makes up the D-alanine branch of the peptidoglycan biosynthetic route. It is a monomer with one pyridoxal phosphate per subunit. In E. coli, the ortholog is duplicated so that a second isozyme, DadX, is present. DadX, a paralog of the biosynthetic Alr, is induced by D- or L-alanine and is involved in catabolism. |
| References | DR PROSITE; PDOC00332;
SE TIGR
GA hmmls
AL clustalw
DR HAMAP; MF_01201; 227 of 233 |
| Genome Property | GenProp0158: peptidoglycan(murein) biosynthesis (HMM) |
