Accession | TIGR00504 |
Name | pyro_pdase |
Function | pyroglutamyl-peptidase I |
Gene Symbol | pcp |
Trusted Cutoff | 201.75 |
Domain Trusted Cutoff | 201.75 |
Noise Cutoff | 113.65 |
Domain Noise Cutoff | 113.65 |
Isology Type | equivalog |
EC Number | 3.4.19.3 |
HMM Length | 213 |
Mainrole Category | Protein fate |
Subrole Category | Degradation of proteins, peptides, and glycopeptides |
Gene Ontology Term | GO:0004219: pyroglutamyl-peptidase I activity molecular_function |
| GO:0030163: protein catabolic process biological_process |
Author | Haft DH |
Entry Date | Apr 20 1999 2:09PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Alternate names include pyroglutamate aminopeptidase, pyrrolidone-carboxylate peptidase, and 5-oxoprolyl-peptidase. It removes pyroglutamate (pyrrolidone-carboxylate, a modified glutamine) that can otherwise block hydrolysis of a polypeptide at the amino end, and so can be extremely useful in the biochemical studies of proteins. The biological role in the various species in which it is found is not fully understood. The enzyme appears to be a homodimer. It does not closely resemble any other peptidases. |
References | SE TIGR
GA hmmls
AL clustalw
DR HAMAP; MF_00417; 97 of 102 |