| Accession | TIGR00507 |
| Name | aroE |
| Function | shikimate 5-dehydrogenase |
| Gene Symbol | aroE |
| Trusted Cutoff | 200.20 |
| Domain Trusted Cutoff | 200.20 |
| Noise Cutoff | 124.50 |
| Domain Noise Cutoff | 124.50 |
| Isology Type | equivalog_domain |
| EC Number | 1.1.1.25 |
| HMM Length | 270 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Aromatic amino acid family |
| Gene Ontology Term | GO:0004764: shikimate 3-dehydrogenase (NADP+) activity molecular_function |
| | GO:0009423: chorismate biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Oct 12 1999 5:46PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM finds proteins from prokaryotes and functionally equivalent domains from larger, multifunctional proteins of fungi and plants. Below the trusted cutoff of 180, but above the noise cutoff of 20, are the putative shikimate dehydrogenases of Thermotoga maritima and Mycobacterium tuberculosis, and uncharacterized paralogs of shikimate dehydrogenase from E. coli and H. influenzae. The related enzyme quinate 5-dehydrogenase scores below the noise cutoff. A neighbor-joining tree, constructed with quinate 5-dehydrogenases as the outgroup, shows the Clamydial homolog as clustering among the shikimate dehydrogenases, although the sequence is unusual in the degree of sequence divergence and the presence of an additional N-terminal domain. |
| References | DR HAMAP; MF_00222; 310 of 327 |
| Genome Property | GenProp0001: chorismate biosynthesis via shikimate (HMM) |
