HMM Summary Page: TIGR00510

Functionlipoyl synthase
Gene SymbollipA
Trusted Cutoff310.25
Domain Trusted Cutoff310.25
Noise Cutoff187.30
Domain Noise Cutoff187.30
Isology Typeequivalog
EC Number2.8.1.8
HMM Length302
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryLipoate
Gene Ontology TermGO:0009107: lipoate biosynthetic process biological_process
GO:0017140: lipoic acid synthase activity molecular_function
AuthorHaft DH
Entry DateOct 15 1999 3:13PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is an iron-sulfur protein. It is localized to mitochondria in yeast and Arabidopsis. It generates lipoic acid, a thiol antioxidant that is linked to a specific Lys as prosthetic group for the pyruvate and alpha-ketoglutarate dehydrogenase complexes and the glycine-cleavage system. The family shows strong sequence conservation.
ReferencesAL ClustalW RN [1] RM 93352559 RT Isolation and characterization of LIP5. A lipoate biosynthetic locus of Saccharomyces cerevisiae. RA Sulo P, Martin NC RL J Biol Chem 1993 Aug 15;268(23):17634-9 RN [2] RM 99330162 RT The lipoate synthase from Escherichia coli is an iron-sulfur protein. RA Ollagnier-de Choudens S, Fontecave M RL FEBS Lett 1999 Jun 18;453(1-2):25-8 DR HAMAP; MF_00206; 384 of 391
Genome PropertyGenProp0745: lipoyl-protein attachment (HMM)