HMM Summary Page: TIGR00521

Functionphosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase
Gene SymbolcoaBC
Trusted Cutoff219.70
Domain Trusted Cutoff219.70
Noise Cutoff211.10
Domain Noise Cutoff211.10
Isology Typeequivalog
EC Number4.1.1.36
HMM Length392
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPantothenate and coenzyme A
Gene Ontology TermGO:0004632: phosphopantothenate--cysteine ligase activity molecular_function
GO:0004633: phosphopantothenoylcysteine decarboxylase activity molecular_function
GO:0015937: coenzyme A biosynthetic process biological_process
GO:0015939: pantothenate metabolic process biological_process
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedAug 24 2011 4:20PM
CommentThis HMM represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC, and decarboxylation, EC in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity.
ReferencesRN [1] RM 11278255 RT Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria. RA Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP. RL J Biol Chem 2001 Apr 27;276(17):13513-6 RN [2] RM 88115193 RT beta-Alanine auxotrophy associated with dfp, a locus affecting DNA synthesis in Escherichia coli. RA Spitzer ED, Jimenez-Billini HE, Weiss B RL J Bacteriol 1988 Feb;170(2):872-6
Genome PropertyGenProp0171: coenzyme A biosynthesis from pantothenate (HMM)
GenProp0171: coenzyme A biosynthesis from pantothenate (HMM)