|Function||phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase|
|Domain Trusted Cutoff||219.70|
|Domain Noise Cutoff||211.10|
|EC Number||18.104.22.168 22.214.171.124|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Subrole Category||Pantothenate and coenzyme A|
|Gene Ontology Term||GO:0004632: phosphopantothenate--cysteine ligase activity molecular_function|
| ||GO:0004633: phosphopantothenoylcysteine decarboxylase activity molecular_function|
| ||GO:0015937: coenzyme A biosynthetic process biological_process|
| ||GO:0015939: pantothenate metabolic process biological_process|
|Entry Date||Oct 18 1999 5:03PM|
|Last Modified||Aug 24 2011 4:20PM|
|Comment||This HMM represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 126.96.36.199, and decarboxylation, EC 188.8.131.52) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity.|
RT Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria.
RA Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP.
RL J Biol Chem 2001 Apr 27;276(17):13513-6
RT beta-Alanine auxotrophy associated with dfp, a locus affecting DNA synthesis in Escherichia coli.
RA Spitzer ED, Jimenez-Billini HE, Weiss B
RL J Bacteriol 1988 Feb;170(2):872-6|
|Genome Property||GenProp0171: coenzyme A biosynthesis from pantothenate (HMM)|
| ||GenProp0171: coenzyme A biosynthesis from pantothenate (HMM)|
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