HMM Summary Page: TIGR00525

AccessionTIGR00525
NamefolB
Functiondihydroneopterin aldolase
Gene SymbolfolB
Trusted Cutoff72.15
Domain Trusted Cutoff72.15
Noise Cutoff23.40
Domain Noise Cutoff23.40
Isology Typeequivalog
EC Number4.1.2.25
HMM Length116
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryFolic acid
Gene Ontology TermGO:0004150: dihydroneopterin aldolase activity molecular_function
GO:0004150: dihydroneopterin aldolase activity molecular_function
GO:0004150: dihydroneopterin aldolase activity molecular_function
GO:0006760: folic acid-containing compound metabolic process biological_process
GO:0006760: folic acid-containing compound metabolic process biological_process
GO:0006760: folic acid-containing compound metabolic process biological_process
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a bacterial dihydroneopterin aldolase, shown to form homo-octamers in E. coli. The equivalent activity is catalyzed by domains of larger folate biosynthesis proteins in other systems. The closely related parologous enzyme in E. coli, dihydroneopterin triphosphate epimerase, which is also homo-octameric, and dihydroneopterin aldolase domains of larger proteins, score below the trusted cutoff but may score well above the noise cutoff.
ReferencesA2 hmmalign AL ClustalW_manual RM 98316300 RT Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase. RA Haussmann C, Rohdich F, Schmidt E, Bacher A, Richter G RL J Biol Chem 1998 Jul 10;273(28):17418-24
Genome PropertyGenProp0038: tetrahydrofolate biosynthesis from GTP and PABA (HMM)
GenProp0038: tetrahydrofolate biosynthesis from GTP and PABA (HMM)
GenProp0038: tetrahydrofolate biosynthesis from GTP and PABA (HMM)