|Function||hydroxymethylglutaryl-CoA reductase, degradative|
|Domain Trusted Cutoff||259.95|
|Domain Noise Cutoff||71.45|
|Mainrole Category||Energy metabolism|
|Gene Ontology Term||GO:0004420: hydroxymethylglutaryl-CoA reductase (NADPH) activity molecular_function|
| ||GO:0016054: organic acid catabolic process biological_process|
|Entry Date||Oct 19 1999 4:29PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Most known examples of hydroxymethylglutaryl-CoA reductase are NADP-dependent (EC 220.127.116.11) from eukaryotes and archaea, involved in the biosynthesis of mevalonate from 3-hydroxy-3-methylglutaryl-CoA. This model, in contrast, is built from the two examples in completed genomes of sequences closely related to the degradative, NAD-dependent hydroxymethylglutaryl-CoA reductase of Pseudomonas mevalonii, a bacterium that can use mevalonate as its sole carbon source.
DR PROSITE; PDOC00064; Hydroxymethylglutaryl-coenzyme A reductase signatures and profile
RT Cloning, sequencing, and overexpression of mvaA, which encodes Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.
RA Beach MJ, Rodwell VW
RL J Bacteriol 1989 Jun;171(6):2994-3001
DR SWISSPROT; P13702; MVAA_PSEMV;
|Genome Property||GenProp0047: IPP biosynthesis via mevalonate (HMM)|
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