HMM Summary Page: TIGR00533

Functionhydroxymethylglutaryl-CoA reductase (NADPH)
Gene SymbolhmgA
Trusted Cutoff441.80
Domain Trusted Cutoff441.80
Noise Cutoff204.70
Domain Noise Cutoff204.70
Isology Typeequivalog_domain
EC Number1.1.1.34
HMM Length402
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOther
Gene Ontology TermGO:0004420: hydroxymethylglutaryl-CoA reductase (NADPH) activity molecular_function
GO:0008299: isoprenoid biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents archaeal examples of the enzyme hydroxymethylglutaryl-CoA reductase (NADP) (EC and the catalytic domain of eukaryotic examples, which also contain a hydrophobic N-terminal domain. This enzyme synthesizes mevalonate, a precursor of isopentenyl pyrophosphate (IPP), a building block for the synthesis of cholesterol, isoprenoids, and other molecules. A related hydroxymethylglutaryl-CoA reductase, typified by an example from Pseudomonas mevalonii, is NAD-dependent and catabolic.
ReferencesA2 hmmalign DR PROSITE; PDOC00064; Hydroxymethylglutaryl-coenzyme A reductase signatures and profile AL ClustalW
Genome PropertyGenProp0047: IPP biosynthesis via mevalonate (HMM)