| Accession | TIGR00538 |
| Name | hemN |
| Function | oxygen-independent coproporphyrinogen III oxidase |
| Gene Symbol | hemN |
| Trusted Cutoff | 324.95 |
| Domain Trusted Cutoff | 324.95 |
| Noise Cutoff | 261.65 |
| Domain Noise Cutoff | 261.65 |
| Isology Type | equivalog |
| EC Number | 1.3.99.22 |
| HMM Length | 454 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Heme, porphyrin, and cobalamin |
| Gene Ontology Term | GO:0006779: porphyrin-containing compound biosynthetic process biological_process |
| | GO:0051989: coproporphyrinogen dehydrogenase activity molecular_function |
| Author | Haft DH |
| Entry Date | Oct 19 1999 4:29PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents HemN, the oxygen-independent coproporphyrinogen III oxidase that replaces HemF function under anaerobic conditions. Several species, including E. coli, Helicobacter pylori, and Aquifex aeolicus, have both a member of this family and a member of another, closely related family for which there is no evidence of coproporphyrinogen III oxidase activity. Members of this family have a perfectly conserved motif PYRT[SC]YP in a region N-terminal to the region of homology with the related uncharacterized protein. |
| References | A2 hmmalign |
| Genome Property | GenProp0221: protoporphyrin IX biosynthesis from uroporphyrinogen III (HMM) |
