HMM Summary Page: TIGR00538

Functionoxygen-independent coproporphyrinogen III oxidase
Gene SymbolhemN
Trusted Cutoff324.95
Domain Trusted Cutoff324.95
Noise Cutoff261.65
Domain Noise Cutoff261.65
Isology Typeequivalog
EC Number1.3.99.22
HMM Length454
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0006779: porphyrin-containing compound biosynthetic process biological_process
GO:0051989: coproporphyrinogen dehydrogenase activity molecular_function
AuthorHaft DH
Entry DateOct 19 1999 4:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents HemN, the oxygen-independent coproporphyrinogen III oxidase that replaces HemF function under anaerobic conditions. Several species, including E. coli, Helicobacter pylori, and Aquifex aeolicus, have both a member of this family and a member of another, closely related family for which there is no evidence of coproporphyrinogen III oxidase activity. Members of this family have a perfectly conserved motif PYRT[SC]YP in a region N-terminal to the region of homology with the related uncharacterized protein.
ReferencesA2 hmmalign
Genome PropertyGenProp0221: protoporphyrin IX biosynthesis from uroporphyrinogen III (HMM)