|Function||histidine decarboxylase, pyruvoyl type|
|Domain Trusted Cutoff||346.65|
|Domain Noise Cutoff||200.50|
|Mainrole Category||Energy metabolism|
|Subrole Category||Amino acids and amines|
|Gene Ontology Term||GO:0004398: histidine decarboxylase activity molecular_function|
| ||GO:0006547: histidine metabolic process biological_process|
|Entry Date||Oct 19 1999 4:29PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This enzyme converts histadine to histamine in a single step by catalyzing the release of CO2. This type is synthesized as an inactive single chain precursor, then cleaved into two chains. The Ser at the new N-terminus at the cleavage site is converted to a pyruvoyl group essential for activity. This type of histidine decarboxylase appears is known so far only in some Gram-positive bacteria, where it may play a role in amino acid catabolism. There is also a pyridoxal phosphate type histidine decarboxylase, as found in human, where histamine is a biologically active amine.
RT Cloning, sequencing, expression, and site-directed mutagenesis of the gene from Clostridium perfringens encoding pyruvoyl-dependent histidine decarboxylase.
RA van Poelje PD, Snell EE
RL Biochemistry 1990 Jan 9;29(1):132-9
|Genome Property||GenProp0872: decarboxylation/antiport proton-motive cycle: histidine-histamine (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer