| Accession | TIGR00543 |
| Name | isochor_syn |
| Function | isochorismate synthase |
| Trusted Cutoff | 224.75 |
| Domain Trusted Cutoff | 224.75 |
| Noise Cutoff | 214.35 |
| Domain Noise Cutoff | 214.35 |
| Isology Type | subfamily |
| EC Number | 5.4.4.2 |
| HMM Length | 349 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Menaquinone and ubiquinone |
| Gene Ontology Term | GO:0005737: cytoplasm cellular_component |
| | GO:0008909: isochorismate synthase activity molecular_function |
| | GO:0009234: menaquinone biosynthetic process biological_process |
| Author | Selengut J, Haft DH |
| Entry Date | Oct 19 1999 4:29PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. |
| References | A2 hmmalign
RM 99013725
RT The role of isochorismate hydroxymutase genes entC and menF in enterobactin and menaquinone biosynthesis in Escherichia coli.
RA Dahm C, Muller R, Schulte G, Schmidt K, Leistner E
RL Biochim Biophys Acta 1998 Oct 23;1425(2):377-86
AL ClustalW_manual |
| Genome Property | GenProp0058: menaquinone biosynthesis via SEPHCHC (HMM) |
| | GenProp1058: 2,3-dihydroxybenzoate biosynthesis (HMM) |
