HMM Summary Page: TIGR00544

Functionprolipoprotein diacylglyceryl transferase
Gene Symbollgt
Trusted Cutoff118.90
Domain Trusted Cutoff118.90
Noise Cutoff76.80
Domain Noise Cutoff76.80
Isology Typeequivalog
EC Number2.4.99.-
HMM Length280
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0008961: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity molecular_function
GO:0009249: protein lipoylation biological_process
GO:0016021: integral to membrane cellular_component
AuthorHaft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe conversion of lipoprotein precursors into lipoproteins consists of three steps. First, the enzyme described by this model transfers a diacylglyceryl moiety from phosphatidylglycerol to the side chain of a Cys that will become the new N-terminus. Second, the signal peptide is removed by signal peptidase II. Finally, the free amino group of the new N-terminal Cys is acylated by apolipoprotein N-acyltransferase.
ReferencesDR SWISSPROT; P37149; LGT_ECOLI DR ECOCYC; EG12128; lgt DR HAMAP; MF_01147; 383 of 390
Genome PropertyGenProp0061: lipoprotein system lgt/lsp/lnt (HMM)