Accession | TIGR00545 |
Name | lipoyltrans |
Function | lipoyltransferase and lipoate-protein ligase |
Trusted Cutoff | 201.85 |
Domain Trusted Cutoff | 201.85 |
Noise Cutoff | 117.10 |
Domain Noise Cutoff | 117.10 |
Isology Type | subfamily |
HMM Length | 326 |
Mainrole Category | Protein fate |
Subrole Category | Protein modification and repair |
Gene Ontology Term | GO:0006464: protein modification process biological_process |
| GO:0017118: lipoyltransferase activity molecular_function |
Author | Haft DH |
Entry Date | Oct 19 1999 4:30PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. |
References | AL ClustalW_manual
RM 98070355
RT Cloning and expression of a cDNA encoding bovine lipoyltransferase.
RA Fujiwara K, Okamura-Ikeda K, Motokawa Y
RL J Biol Chem 1997 Dec 19;272(51):31974-8
DR HAMAP; MF_01602; 37 of 38 |