HMM Summary Page: TIGR00548

Functionouter membrane lipoprotein LolB
Gene SymbollolB
Trusted Cutoff59.60
Domain Trusted Cutoff59.60
Noise Cutoff54.35
Domain Noise Cutoff54.35
Isology Typeequivalog
HMM Length202
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0008320: protein transmembrane transporter activity molecular_function
GO:0009306: protein secretion biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein, LolB, is known so far only in the gamma and beta subdivisions of the Proteobacteria. It is a processed, lipid-modified outer membrane protein. It is required in E. coli for insertion of the major outer lipoprotein (Lpp) into the outer membrane. Lpp is transferred to LolB from the carrier protein LolA in the periplasm. Previously, this protein was thought to play in role in 5-aminolevulinic acid synthesis and was designated HemM.
ReferencesAL ClustalW RM 98046025 RT A novel outer membrane lipoprotein, LolB (HemM), involved in the LolA (p20)-dependent localization of lipoproteins to the outer membrane of Escherichia coli. RA Matsuyama Si, Yokota N, Tokuda H RL EMBO J 1997 Dec 1;16(23):6947-55 DR HAMAP; MF_00233; 116 of 117
Genome PropertyGenProp0207: lipoprotein localization system lolABCDE (HMM)