HMM Summary Page: TIGR00550

Functionquinolinate synthetase complex, A subunit
Gene SymbolnadA
Trusted Cutoff262.90
Domain Trusted Cutoff262.90
Noise Cutoff106.85
Domain Noise Cutoff106.85
Isology Typeequivalog
EC Number2.5.1.72
HMM Length309
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPyridine nucleotides
Gene Ontology TermGO:0008987: quinolinate synthetase A activity molecular_function
GO:0019363: pyridine nucleotide biosynthetic process biological_process
GO:0019804: quinolinate synthetase complex cellular_component
AuthorHaft DH, Anolik RT
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein, termed NadA, plays a role in the synthesis of pyridine, a precursor to NAD. The quinolinate synthetase complex consists of A protein (this protein) and B protein. B protein converts L-aspartate to iminoaspartate, an unstable reaction product which in the absence of A protein is spontaneously hydrolyzed to form oxaloacetate. The A protein, NadA, converts iminoaspartate to quinolate.
ReferencesGA hmmsearch DR ECOCYC; EG10630; nadA; AL clustalw DR HAMAP; MF_00569; 27 of 27
Genome PropertyGenProp0057: NAD(P) biosynthesis from L-aspartate and DHAP (HMM)