HMM Summary Page: TIGR00552

FunctionNAD+ synthetase
Gene SymbolnadE
Trusted Cutoff63.65
Domain Trusted Cutoff63.65
Noise Cutoff57.50
Domain Noise Cutoff57.50
Isology Typeequivalog_domain
EC Number6.3.1.5
HMM Length251
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPyridine nucleotides
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0008795: NAD+ synthase activity molecular_function
GO:0009435: NAD biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentNAD+ synthetase is a nearly ubiquitous enzyme for the final step in the biosynthesis of the essensial cofactor NAD. The member of this family from Bacillus subtilis is a strictly NH(3)-dependent NAD(+) synthetase of 272 amino acids. Proteins consisting only of the domain modeled here may be named as NH3-dependent NAD+ synthetase. Amidotransferase activity may reside in a separate protein, or not be present. Some other members of the family, such as from Mycobacterium tuberculosis, are considerably longer, contain an apparent amidotransferase domain, and show glutamine-dependent as well as NH(3)-dependent activity.
ReferencesAL clustalw RM 98292757 RT The MTCY428.08 gene of Mycobacterium tuberculosis codes for NAD+ synthetase. RA Cantoni R, Branzoni M, Labo M, Rizzi M, Riccardi G RL J Bacteriol 1998 Jun;180(12):3218-21 DR HAMAP; MF_00193; 189 of 191
Genome PropertyGenProp0057: NAD(P) biosynthesis from L-aspartate and DHAP (HMM)