| Accession | TIGR00553 |
| Name | pabB |
| Function | aminodeoxychorismate synthase, component I |
| Gene Symbol | pabB |
| Trusted Cutoff | 328.40 |
| Domain Trusted Cutoff | 328.40 |
| Noise Cutoff | 327.20 |
| Domain Noise Cutoff | 327.20 |
| Isology Type | equivalog |
| EC Number | 2.6.1.85 |
| HMM Length | 329 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Folic acid |
| Gene Ontology Term | GO:0008153: para-aminobenzoic acid biosynthetic process biological_process |
| | GO:0009396: folic acid-containing compound biosynthetic process biological_process |
| | GO:0046820: 4-amino-4-deoxychorismate synthase activity molecular_function |
| Author | Selengut J, Haft DH |
| Entry Date | Oct 19 1999 4:30PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). |
| References | A2 hmmalign
DR ECOCYC; EG10683; pabB; |
| Genome Property | GenProp0759: para-aminobenzoic acid (PABA) biosynthesis from chorismate (HMM) |
