| Accession | TIGR00559 |
| Name | pdxJ |
| Function | pyridoxine 5'-phosphate synthase |
| Gene Symbol | pdxJ |
| Trusted Cutoff | 192.75 |
| Domain Trusted Cutoff | 192.75 |
| Noise Cutoff | 154.25 |
| Domain Noise Cutoff | 154.25 |
| Isology Type | equivalog |
| EC Number | 2.6.99.2 |
| HMM Length | 239 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pyridoxine |
| Gene Ontology Term | GO:0008615: pyridoxine biosynthetic process biological_process |
| | GO:0033856: pyridoxine 5'-phosphate synthase activity molecular_function |
| Author | Haft DH |
| Entry Date | Oct 19 1999 4:30PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | PdxJ is required in the biosynthesis of pyridoxine (vitamin B6), a precursor to the enzyme cofactor pyridoxal phosphate. ECOCYC describes the predicted reaction equation as 1-amino-propan-2-one-3-phosphate + deoxyxylulose-5-phosphate = pyridoxine-5'-phosphate. The product of that reaction is oxidized by PdxH to pyridoxal 5'-phosphate. |
| References | AL clustalw
DR SWISS-PROT; P24223; PDXJ_ECOLI; annotation and links to references
DR ECOCYC; EG10693; pdxJ;
RM 99239931
RT Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.
RA Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS
RL FEBS Lett 1999 Apr 16;449(1):45-8
DR HAMAP; MF_00279; 166 of 198 |
| Genome Property | GenProp0862: pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway (HMM) |
