HMM Summary Page: TIGR00564

Functionanthranilate synthase component I
Gene SymboltrpE
Trusted Cutoff517.70
Domain Trusted Cutoff517.70
Noise Cutoff516.20
Domain Noise Cutoff516.20
Isology Typeequivalog
EC Number4.1.3.27
HMM Length455
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
Gene Ontology TermGO:0000162: tryptophan biosynthetic process biological_process
GO:0004049: anthranilate synthase activity molecular_function
AuthorSelengut J, Haft DH
Entry DateOct 19 1999 4:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria. A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB.
ReferencesDR PFAM; PF00425; chorismate_bind
Genome PropertyGenProp0037: tryptophan biosynthesis from ribose-5-phosphate (HMM)