HMM Summary Page: TIGR00565

Functionanthranilate synthase component I
Gene SymboltrpE
Trusted Cutoff494.65
Domain Trusted Cutoff494.65
Noise Cutoff341.10
Domain Noise Cutoff341.10
Isology Typeequivalog
EC Number4.1.3.27
HMM Length498
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
Gene Ontology TermGO:0000162: tryptophan biosynthetic process biological_process
GO:0004049: anthranilate synthase activity molecular_function
AuthorHaft DH
Entry DateOct 19 1999 4:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. This group includes proteobacteria such as E. coli and Helicobacter pylori but also the gram-positive organism Corynebacterium glutamicum. The second group includes eukaryotes, archaea, and most other bacterial lineages; sequences from the second group may resemble pabB more closely than other trpE from this group.
ReferencesA2 hmmalign DR PFAM; PF00425; chorismate_bind
Genome PropertyGenProp0037: tryptophan biosynthesis from ribose-5-phosphate (HMM)