| Accession | TIGR00570 |
| Name | cdk7 |
| Function | CDK-activating kinase assembly factor MAT1 |
| Trusted Cutoff | 160.20 |
| Domain Trusted Cutoff | 160.20 |
| Noise Cutoff | 150.65 |
| Domain Noise Cutoff | 150.65 |
| Isology Type | equivalog |
| HMM Length | 309 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0000109: nucleotide-excision repair complex cellular_component |
| | GO:0004693: cyclin-dependent protein kinase activity molecular_function |
| | GO:0005675: holo TFIIH complex cellular_component |
| | GO:0006289: nucleotide-excision repair biological_process |
| | GO:0006352: transcription initiation, DNA-dependent biological_process |
| Author | Loftus BJ, Eisen JA |
| Entry Date | Oct 19 1999 6:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | All proteins in this family for which functions are known are cyclin dependent protein kinases that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. Also known as MAT1 (menage a trois 1). This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). |
| References | A2 hmmalign
DR EGAD; 96906;
DR SWISSPROT: P51949;
RM 96006524
RT Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase.
RA Fisher RP, Jin P, Chamberlin HM, Morgan DO.
RL Cell 1995 Oct 6;83(1):47-57 |
