HMM Summary Page: TIGR00580

Functiontranscription-repair coupling factor
Gene Symbolmfd
Trusted Cutoff819.85
Domain Trusted Cutoff819.85
Noise Cutoff533.00
Domain Noise Cutoff533.00
Isology Typeequivalog
EC Number3.6.1.-
HMM Length923
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003690: double-stranded DNA binding molecular_function
GO:0005515: protein binding molecular_function
GO:0005524: ATP binding molecular_function
GO:0006281: DNA repair biological_process
GO:0016887: ATPase activity molecular_function
AuthorLoftus BJ, Eisen JA
Entry DateOct 19 1999 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentAll proteins in this family for which functions are known are DNA-dependent ATPases that function in the process of transcription-coupled DNA repair in which the repair of the transcribed strand of actively transcribed genes is repaired at a higher rate than the repair of non-transcribed regions of the genome and than the non-transcribed strand of the same gene. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is closely related to the RecG and UvrB families.
ReferencesDR SWISSPROT; P30958; RM 93219833;
Genome PropertyGenProp0229: transcription-coupled nucleotide excision repair (HMM)