Accession | TIGR00581 |
Name | moaC |
Function | molybdenum cofactor biosynthesis protein C |
Gene Symbol | moaC |
Trusted Cutoff | 141.50 |
Domain Trusted Cutoff | 141.50 |
Noise Cutoff | 71.45 |
Domain Noise Cutoff | 71.45 |
Isology Type | equivalog |
HMM Length | 148 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Molybdopterin |
Gene Ontology Term | GO:0003824: catalytic activity molecular_function |
| GO:0006777: Mo-molybdopterin cofactor biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Oct 19 1999 6:19PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | MoaC catalyzes an early step in molybdenum cofactor biosynthesis in E. coli. The Arabidopsis homolog Cnx3 complements MoaC deficiency in E. coli (MUID:95197640). Eukarotic members of this family branch within the bacterial branch, with the archaeal members as an apparent outgroup. This protein is absent in a number of the pathogens with smaller genomes, including Mycoplasmas, Chlamydias, and spirochetes, but is found in most other complete genomes to date. The homolog form Synechocystis sp. is fused to a MobA-homologous region and is an outlier to all other bacterial forms by both neighbor-joining and UPGMA analyses. Members of this family are well-conserved. The seed for this model excludes both archaeal sequences and the most divergent bacterial sequences, but still finds all candidate MoaC sequences easily between trusted and noise cutoffs. We suggest that sequences branching outside the set that contains all seed members be regarded only as putative functional equivalents of MoaC unless and until a member of the archaeal outgroup is shown to have equivalent function. |
References | GA hmmsearch
RN [1]
RM 95197640
RT Isolation of two Arabidopsis cDNAs involved in early steps of molybdenum cofactor biosynthesis by functional complementation of Escherichia coli mutants.
RA Hoff T, Schnorr KM, Meyer C, Caboche M
RL J Biol Chem 1995 Mar 17;270(11):6100-7
DR OUTGROUP; EGAD|105404|AF2150
DR OUTGROUP; EGAD|43752|MJ1135
DR EXPERIMENTAL; EGAD|21351|EC0783;
DR EXPERIMENTAL; EGAD|25607|26408;
DR HAMAP; MF_01224; 228 of 237 |
Genome Property | GenProp0466: molybdopterin biosynthesis (HMM) |