|Function||4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase|
|Domain Trusted Cutoff||280.25|
|Domain Noise Cutoff||159.60|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Gene Ontology Term||GO:0005737: cytoplasm cellular_component|
| ||GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway biological_process|
| ||GO:0046429: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity molecular_function|
|Entry Date||Oct 20 1999 11:45AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis.
Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins.|
RT Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli.
RA Campos N, Rodriguez-Concepcion M, Seemann M, Rohmer M, Boronat A.
RL FEBS Lett 2001 Jan 19;488(3):170-3
RT aarC, an essential gene involved in density-dependent regulation of the 2'-N-acetyltransferase in Providencia stuartii.
RA Rather PN, Solinsky KA, Paradise MR, Parojcic MM
RL J Bacteriol 1997 Apr;179(7):2267-73
DR HAMAP; MF_00159; 301 of 306|
|Genome Property||GenProp0048: IPP biosynthesis via deoxyxylulose (HMM)|
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