HMM Summary Page: TIGR00642

Functionmethylmalonyl-CoA mutase, small subunit
Gene SymbolmutA
Trusted Cutoff617.25
Domain Trusted Cutoff617.25
Noise Cutoff284.30
Domain Noise Cutoff284.30
Isology Typeequivalog
EC Number5.4.99.2
HMM Length620
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOther
Gene Ontology TermGO:0004494: methylmalonyl-CoA mutase activity molecular_function
GO:0008152: metabolic process biological_process
AuthorHaft DH
Entry DateOct 25 1999 11:40AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe adenosylcobalamin-binding, catalytic chain of methylmalonyl-CoA mutase may form homodimers, as in mitochondrion and E. coli, or heterodimers with a shorter, homologous chain that does not bind adenosylcobalamin. This HMM describes this non-catalytic beta chain, as found in the enzyme from Propionibacterium freudenreichii, for which the 3-dimensional structure has been solved.
ReferencesA2 hmmalign RM 97386818 RT Structure-based perspectives on B12-dependent enzymes. RA Ludwig ML, Matthews RG RL Annu Rev Biochem 1997;66:269-313 DR OUTGROUP; EGAD|9936|EC2917
Genome PropertyGenProp0755: pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating (HMM)