Accession | TIGR00653 |
Name | GlnA |
Function | glutamine synthetase, type I |
Gene Symbol | glnA |
Trusted Cutoff | 429.15 |
Domain Trusted Cutoff | 429.15 |
Noise Cutoff | 324.75 |
Domain Noise Cutoff | 324.75 |
Isology Type | equivalog |
EC Number | 6.3.1.2 |
HMM Length | 462 |
Mainrole Category | Amino acid biosynthesis |
Subrole Category | Glutamate family |
Gene Ontology Term | GO:0004356: glutamate-ammonia ligase activity molecular_function |
| GO:0006542: glutamine biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Dec 1 1999 10:45AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation.
|
References | A2 hmmalign
DR ECOCYC; EG10383; glnA;
DR EXPERIMENTAL; EGAD|20324|EC3870;
DR EXPERIMENTAL; EGAD|8994|8799;
RN [1]
RM 99081206
RT The glutamine synthetase from the hyperthermoacidophilic crenarcheon Sulfolobus acidocaldarius: isolation, characterization and sequencing of the gene.
RA Yin Z, Purschke WG, Schafer G, Schmidt CL
RL Biol Chem 1998 Nov;379(11):1349-54
RN [2]
RM 95214531
RT Glutamine synthetase gene evolution in bacteria.
RA Pesole G, Gissi C, Lanave C, Saccone C
RL Mol Biol Evol 1995 Mar;12(2):189-97
|