HMM Summary Page: TIGR00667

Functionleucyl/phenylalanyl-tRNA--protein transferase
Gene Symbolaat
Trusted Cutoff143.55
Domain Trusted Cutoff143.55
Noise Cutoff66.55
Domain Noise Cutoff66.55
Isology Typeequivalog
EC Number2.3.2.6
HMM Length193
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0006508: proteolysis biological_process
GO:0008914: leucyltransferase activity molecular_function
AuthorHaft DH, Loftus BJ
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe N-terminal residue controls the biological half-life of many proteins via the N-end rule pathway. This enzyme transfers a Leu or Phe to the amino end of certain proteins to enable degradation.
ReferencesSE EC/COG AL clustalw RN [1] RM 93322314 RT The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat. RA Shrader TE, Tobias JW, Varshavsky A RL J Bacteriol 1993 Jul;175(14):4364-74 RN [2] RM 95386512 DR ECOCYC; EG11112; aat DR EXPERIMENTAL; EGAD|20052|EC0885; Escherichia coli DR HAMAP; MF_00688; 213 of 216