|Domain Trusted Cutoff||236.95|
|Domain Noise Cutoff||186.45|
|Mainrole Category||Purines, pyrimidines, nucleosides, and nucleotides|
|Subrole Category||Pyrimidine ribonucleotide biosynthesis|
|Gene Ontology Term||GO:0004070: aspartate carbamoyltransferase activity molecular_function|
| ||GO:0009220: pyrimidine ribonucleotide biosynthetic process biological_process|
|Entry Date||Jan 13 2000 2:40PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Aspartate transcarbamylase (ATCase) is an alternate name.
PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.
Ornithine carbamoyltransferases are in the same superfamily and form an outgroup.
DR PFAM; PF00185; OTCace; superfamily HMM
DR PFAM; PF01948; PyrI; regulatory partner HMM
DR ECOCYC; EG10805; pyrB
DR EXPERIMENTAL; EGAD|16102|BS1550
DR EXPERIMENTAL; EGAD|13385|EC4245
DR EXPERIMENTAL; EGAD|124709|TM1642
DR OUTGROUP; EGAD|104419|AF1255; ornithine carbamoyltransferase
RT A reappraisal of the diversity and class distribution of aspartate transcarbamoylases in gram-negative bacteria.
RA Kenny MJ, McPhail D, Shepherdson M
RL Microbiology 1996 Jul;142 ( Pt 7):1873-9
DR HAMAP; MF_00001; 502 of 510|
|Genome Property||GenProp0187: pyrimidine (uridine-5'-phosphate) de novo biosynthesis (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer