HMM Summary Page: TIGR00674

Function4-hydroxy-tetrahydrodipicolinate synthase
Gene SymboldapA
Trusted Cutoff206.15
Domain Trusted Cutoff206.15
Noise Cutoff177.55
Domain Noise Cutoff177.55
Isology Typeequivalog
EC Number4.3.3.7
HMM Length286
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0008840: dihydrodipicolinate synthase activity molecular_function
GO:0009089: lysine biosynthetic process via diaminopimelate biological_process
AuthorHaft DH
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are 4-hydroxy-tetrahydrodipicolinate synthase, previously (incorrectly) called dihydrodipicolinate synthase. It is a homotetrameric enzyme of lysine biosynthesis. E. coli has several paralogs closely related to dihydrodipicoline synthase (DapA), as well as the more distant N-acetylneuraminate lyase. In Pyrococcus horikoshii, the bidirectional best hit with E. coli is to an uncharacterized paralog of DapA, not DapA itself, and it is omitted from the seed. The putative members from the Chlamydias (pathogens with a parasitic metabolism) are easily the most divergent members of the multiple alignment.
ReferencesDR EXPERIMENTAL; EGAD|128581|137272; poplar DR EXPERIMENTAL; EGAD|128579|137270; tobacco DR EXPERIMENTAL; EGAD|14906|EC2478; E. coli DR EXPERIMENTAL; EGAD|10095|9900; Corynebacterium glutamicum DR EXCEPTION; >EGAD|14762|14776; MosA; Rhizobium meliloti DR OUTGROUP; EGAD|29522|EC3225; N-acetylneuraminate lyase DR PFAM; PF00701; DHDPS; dihydrodipicolinate synthase superfamily DR HAMAP; MF_00418; 355 of 370
Genome PropertyGenProp0125: lysine biosynthesis via diaminopimelate (DAP) (HMM)
GenProp0788: lysine biosynthesis via diaminopimelate (DAP) utilizing ammonia and NADPH (HMM)