Accession | TIGR00677 |
Name | fadh2_euk |
Function | methylenetetrahydrofolate reductase |
Trusted Cutoff | 310.05 |
Domain Trusted Cutoff | 310.05 |
Noise Cutoff | 301.80 |
Domain Noise Cutoff | 301.80 |
Isology Type | equivalog |
EC Number | 1.5.1.20 |
HMM Length | 281 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Folic acid |
Gene Ontology Term | GO:0004489: methylenetetrahydrofolate reductase (NADPH) activity molecular_function |
| GO:0009396: folic acid-containing compound biosynthetic process biological_process |
Author | Loftus BJ, Haft DH |
Entry Date | Jan 13 2000 2:40PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in eukaryotes and designated 1.5.1.20.
This protein is an FAD-containing flavoprotein. |
References | A2 hmmalign
SE COG/EC
AL clustalw
DR OUTGROUP; EGAD|20689|EC3941; Escherichia coli
DR EXPERIMENTAL; EGAD|4286|4234; Homo sapiens
DR EXPERIMENTAL; GP|5911425|gb|AAD55787.1|AF181966_1|AF181966 |