Accession | TIGR00683 |
Name | nanA |
Function | N-acetylneuraminate lyase |
Gene Symbol | nanA |
Trusted Cutoff | 382.00 |
Domain Trusted Cutoff | 382.00 |
Noise Cutoff | 154.10 |
Domain Noise Cutoff | 154.10 |
Isology Type | equivalog |
EC Number | 4.1.3.3 |
HMM Length | 293 |
Mainrole Category | Cell envelope |
Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
Gene Ontology Term | GO:0006040: amino sugar metabolic process biological_process |
| GO:0008747: N-acetylneuraminate lyase activity molecular_function |
| GO:0009273: peptidoglycan-based cell wall biogenesis biological_process |
Author | Haft DH |
Entry Date | Jan 13 2000 2:40PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | N-acetylneuraminate lyase is also known as N-acetylneuraminic acid aldolase, sialic acid aldolase, or sialate lyase. It is an intracellular enzyme. The structure of this homotetrameric enzyme related to dihydrodipicolinate synthase is known. In Clostridium tertium, the enzyme appears to be in an operon with a secreted sialidase that releases sialic acid from host sialoglycoconjugates. In several E. coli strains, however, this enzyme is responsible for N-acetyl-D-neuraminic acid synthesis for capsule production by condensing N-acetyl-D-mannosamine and pyruvate. |
References | RN [1]
RM 98205111
RT Expression in Escherichia coli of the putative N-acetylneuraminate lyase gene (nanA) from Haemophilus influenzae: overproduction, purification, and crystallization.
RA Lilley GG, Barbosa JA, Pearce LA
RL Protein Expr Purif 1998 Apr;12(3):295-304
RN [2]
RM 99054726
DR EXPERIMENTAL; EGAD|29522|EC3225; Escherichia coli
DR EXPERIMENTAL; EGAD|27817|HI0142; Haemophilus influenzae
DR EXPERIMENTAL; EGAD|150412|160512; Trichomonas vaginalis
DR OUTGROUP; EGAD|14906|EC2478; dihydrodipicolinate synthase
DR HAMAP; MF_01237; 30 of 49 |