HMM Summary Page: TIGR00684

Functionnitrate reductase molybdenum cofactor assembly chaperone
Gene SymbolnarJ
Trusted Cutoff59.35
Domain Trusted Cutoff59.35
Noise Cutoff48.55
Domain Noise Cutoff48.55
Isology Typeequivalog
HMM Length152
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
Gene Ontology TermGO:0051082: unfolded protein binding molecular_function
GO:0051131: chaperone-mediated protein complex assembly biological_process
AuthorHaft DH, Loftus BJ
Entry DateJan 13 2000 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein is termed NarJ in most species that have a single copy, and has been called the delta subunit of nitrate reductase. However, although it is required for correct assembly of active enzyme, it dissociates and is not part of the enzyme. Two hits to this HMM are found each in E. coli and in Mycobacterium tuberculosis, but in each case duplication to create paralogs appears to be recent. The NarX protein of Mycobacterium tuberculosis includes one of these paralogs as a domain, fused to structural domains of nitrate reductases before and after the NarJ-homologous region.
ReferencesRM 98294038 RT NarJ is a specific chaperone required for molybdenum cofactor assembly in nitrate reductase A of Escherichia coli. RA Blasco F, Dos Santos JP, Magalon A, Frixon C, Guigliarelli B, Santini CL, Giordano G RL Mol Microbiol 1998 May;28(3):435-47
Genome PropertyGenProp0636: respiratory nitrate reductase (HMM)