HMM Summary Page: TIGR00696

Functionglycosyltransferase, WecB/TagA/CpsF family
Trusted Cutoff69.00
Domain Trusted Cutoff69.00
Noise Cutoff37.80
Domain Noise Cutoff37.80
Isology Typesuperfamily
EC Number2.4.1.-
HMM Length178
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0016757: transferase activity, transferring glycosyl groups molecular_function
GO:0043163: cell envelope organization biological_process
AuthorHaft DH, Loftus BJ
Entry DateJan 13 2000 2:41PM
Last ModifiedNov 15 2011 9:42AM
CommentThe WecG member of this superfamily, believed to be UDP-N-acetyl-D-mannosaminuronic acid transferase, plays a role in enterobacterial common antigen (eca) synthesis in Escherichia coli. Another family member, the Bacillus subtilis TagA protein, is involved in the biosynthesis of the cell wall polymer poly(glycerol phosphate). The third family member, CpsF, CMP-N-acetylneuraminic acid synthetase has a role in the capsular polysaccharide biosynthesis pathway.
ReferencesDR ECOCYC; EG11458; wecG RM 96228704 RT Characterization of cpsF and its product CMP-N-acetylneuraminic acid synthetase, a group B streptococcal enzyme that can function in K1 capsular polysaccharide biosynthesis in Escherichia coli. RA Haft RF, Wessels MR, Mebane MF, Conaty N, Rubens CE RL Mol Microbiol 1996 Feb;19(3):555-63 DR HAMAP; MF_01001; 32 of 33
Genome PropertyGenProp0973: Enterobacterial common antigen (ECA) (HMM-CLUST)