|Function||signal peptide peptidase SppA, 67K type|
|Domain Trusted Cutoff||311.45|
|Domain Noise Cutoff||229.00|
|Mainrole Category||Protein fate|
|Subrole Category||Degradation of proteins, peptides, and glycopeptides|
|Gene Ontology Term||GO:0006508: proteolysis biological_process|
|Entry Date||Feb 1 2000 10:52AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This HMM represents the signal peptide peptidase A (SppA, protease IV) as found in E. coli, Treponema pallidum, Mycobacterium leprae, and several other species, in which it has a molecular mass around 67 kDa and a duplication such that the N-terminal half shares extensive homology with the C-terminal half. This enzyme was shown in E. coli to form homotetramers.
E. coli SohB, which is most closely homologous to the C-terminal duplication of SppA, is predicted to perform a similar function of small peptide degradation, but in the periplasm. Many prokaryotes have a single SppA/SohB homolog that may perform the function of either or both.|
DR EXPERIMENTAL; EGAD|20229|EC1766
RT Characterization of the sppA gene coding for protease IV, a signal peptide peptidase of Escherichia coli.
RA Suzuki T, Itoh A, Ichihara S, Mizushima S
RL J Bacteriol 1987 Jun;169(6):2523-8|
|Genome Property||GenProp0205: signal recognition system, bacterial (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer