| Accession | TIGR00705 |
| Name | SppA_67K |
| Function | signal peptide peptidase SppA, 67K type |
| Gene Symbol | sppA |
| Trusted Cutoff | 311.45 |
| Domain Trusted Cutoff | 311.45 |
| Noise Cutoff | 229.00 |
| Domain Noise Cutoff | 229.00 |
| Isology Type | equivalog |
| EC Number | 3.4.-.- |
| HMM Length | 590 |
| Mainrole Category | Protein fate |
| Subrole Category | Degradation of proteins, peptides, and glycopeptides |
| Gene Ontology Term | GO:0006508: proteolysis biological_process |
| Author | Haft DH |
| Entry Date | Feb 1 2000 10:52AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the signal peptide peptidase A (SppA, protease IV) as found in E. coli, Treponema pallidum, Mycobacterium leprae, and several other species, in which it has a molecular mass around 67 kDa and a duplication such that the N-terminal half shares extensive homology with the C-terminal half. This enzyme was shown in E. coli to form homotetramers.
E. coli SohB, which is most closely homologous to the C-terminal duplication of SppA, is predicted to perform a similar function of small peptide degradation, but in the periplasm. Many prokaryotes have a single SppA/SohB homolog that may perform the function of either or both. |
| References | A2 hmmalign
AL clustalw
DR EXPERIMENTAL; EGAD|20229|EC1766
RN [1]
RM 87222172
RT Characterization of the sppA gene coding for protease IV, a signal peptide peptidase of Escherichia coli.
RA Suzuki T, Itoh A, Ichihara S, Mizushima S
RL J Bacteriol 1987 Jun;169(6):2523-8 |
| Genome Property | GenProp0205: signal recognition system, bacterial (HMM) |
