HMM Summary Page: TIGR00706

Functionsignal peptide peptidase SppA, 36K type
Gene SymbolsppA
Trusted Cutoff155.45
Domain Trusted Cutoff155.45
Noise Cutoff97.75
Domain Noise Cutoff97.75
Isology Typeequivalog_domain
EC Number3.4.-.-
HMM Length208
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0006465: signal peptide processing biological_process
GO:0008981: protease IV activity molecular_function
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe related but duplicated, double-length protein SppA (protease IV) of E. coli was shown experimentally to degrade signal peptides as are released by protein processing and secretion. This protein shows stronger homology to the C-terminal region of SppA than to the N-terminal domain or to the related putative protease SuhB. The member of this family from Bacillus subtilis was shown to have properties consistent with a role in degrading signal peptides after cleavage from precursor proteins, although it was not demonstrated conclusively.
ReferencesA2 hmmalign AL clustalw RM 99386931 RT Signal peptide peptidase- and ClpP-like proteins of Bacillus subtilis required for efficient translocation and processing of secretory proteins. RA Bolhuis A, Matzen A, Hyyrylainen HL, Kontinen VP, Meima R, Chapuis J, Venema G, Bron S, Freudl R, van Dijl JM RL J Biol Chem 1999 Aug 27;274(35):24585-92
Genome PropertyGenProp0205: signal recognition system, bacterial (HMM)