| Accession | TIGR00711 |
| Name | efflux_EmrB |
| Function | drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family |
| Trusted Cutoff | 230.20 |
| Domain Trusted Cutoff | 230.20 |
| Noise Cutoff | 175.95 |
| Domain Noise Cutoff | 175.95 |
| Isology Type | subfamily |
| HMM Length | 485 |
| Mainrole Category | Cellular processes |
| Subrole Category | Toxin production and resistance |
| Gene Ontology Term | GO:0005887: integral to plasma membrane cellular_component |
| | GO:0006855: drug transmembrane transport biological_process |
| | GO:0015307: drug:hydrogen antiporter activity molecular_function |
| | GO:0042493: response to drug biological_process |
| Author | Haft DH |
| Entry Date | Feb 1 2000 10:52AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. |
| References | A2 hmmalign
AL clustalw
RN [1]
RM 98125732
RN [2]
RM 93028382 |
