HMM Summary Page: TIGR00729
| Accession | TIGR00729 |
| Name | TIGR00729 |
| Function | ribonuclease HII |
| Gene Symbol | rnhB |
| Trusted Cutoff | 123.30 |
| Domain Trusted Cutoff | 123.30 |
| Noise Cutoff | 97.80 |
| Domain Noise Cutoff | 97.80 |
| Isology Type | equivalog |
| EC Number | 3.1.26.4 |
| HMM Length | 207 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0004523: ribonuclease H activity molecular_function |
| GO:0006401: RNA catabolic process biological_process | |
| Author | Haft DH |
| Entry Date | Feb 22 2000 11:31AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme cleaves RNA from DNA-RNA hybrids. Archaeal members of this subfamily of RNase H are designated RNase HII and one has been shown to be active as a monomer. A member from Homo sapiens was characterized as RNase HI, large subunit. |
| References | AL clustalw_manual DR EXPERIMENTAL; GP|3551209|dbj|BAA32803.1||AB012613; Pyrococcus kodakaraensis DR EXPERIMENTAL; GP|3334761|emb|CAB09725.1||Z97029; Homo sapiens RN [1] RM 99047566 RT Gene cloning and characterization of recombinant RNase HII from a hyperthermophilic archaeon. RA Haruki M, Hayashi K, Kochi T, Muroya A, Koga Y, Morikawa M, Imanaka T, Kanaya S RL J Bacteriol 1998 Dec;180(23):6207-14 RN [2] RM 99007233 RT Cloning of the cDNA encoding the large subunit of human RNase HI, a homologue of the prokaryotic RNase HII. RA Frank P, Braunshofer-Reiter C, Wintersberger U, Grimm R, Busen W RL Proc Natl Acad Sci U S A 1998 Oct 27;95(22):12872-7 DR HAMAP; MF_00052; 42 of 548 |